Statin Therapy Reduces the Mycobacterium tuberculosis Burden in Human Macrophages and in Mice by Enhancing Autophagy and Phagosome Maturation | Zendy

Suraj P. Parihar | Zendy; Reto Guler | Zendy; Rethabile Khutlang | Zendy; Dirk Lang | Zendy; Ramona Hurdayal | Zendy; Musa M. Mhlanga | Zendy; Harukazu Suzuki | Zendy; A. David Marais | Zendy; Frank Brombacher | Zendy

Open Access

Statin Therapy Reduces the Mycobacterium tuberculosis Burden in Human Macrophages and in Mice by Enhancing Autophagy and Phagosome Maturation

Author(s) -

Suraj P. Parihar,

Reto Guler,

Rethabile Khutlang,

Dirk Lang,

Ramona Hurdayal,

Musa M. Mhlanga,

Harukazu Suzuki,

A. David Marais,

Frank Brombacher

Publication year - 2013

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1093/infdis/jit550

Subject(s) - autophagy , mycobacterium tuberculosis , tuberculosis , phagosome , immunology , statin , cholesterol , macrophage , peripheral blood mononuclear cell , phagocytosis , monocyte , medicine , microbiology and biotechnology , biology , pharmacology , pathology , biochemistry , apoptosis , in vitro

Statins are cholesterol-lowering drugs, targeting HMG-CoA reductase, thereby reducing the risk of coronary disorders and hypercholesterolemia. However, they also can influence immunologic responses.

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