Efficacy of Influenza Vaccination of Elderly Rhesus Macaques Is Dramatically Improved by Addition of a Cationic Lipid/DNA Adjuvant | Zendy

Timothy D. Carroll | Zendy; Shan R. Matzinger | Zendy; Peter Barry | Zendy; Michael B. McChesney | Zendy; Jeff Fairman | Zendy; C. J. Miller | Zendy

Open Access

Efficacy of Influenza Vaccination of Elderly Rhesus Macaques Is Dramatically Improved by Addition of a Cationic Lipid/DNA Adjuvant

Author(s) -

Timothy D. Carroll,

Shan R. Matzinger,

Peter Barry,

Michael B. McChesney,

Jeff Fairman,

C. J. Miller

Publication year - 2013

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1093/infdis/jit540

Subject(s) - vaccination , adjuvant , virology , dna vaccination , medicine , immunology , dna , biology , immune system , immunization , genetics

The decreased immune response among elderly individuals results in reduced influenza vaccine efficacy. Strategies to improve vaccine efficacy in elderly individuals are needed. The goal of this study was to determine whether a cationic lipid/DNA complex (CLDC) can improve the efficacy of the trivalent inactivated influenza vaccine Fluzone in elderly nonhuman primates.

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