Genital Herpes Simplex Virus Type 2 Infection in Humanized HIV-Transgenic Mice Triggers HIV Shedding and Is Associated With Greater Neurological Disease | Zendy

Briana G. Nixon | Zendy; Esra Fakioglu | Zendy; Martha Stefanidou | Zendy; Yingying Wang | Zendy; Mousumi Dutta | Zendy; HARRIS GOLDSTEIN | Zendy; Betsy C. Herold | Zendy

Open Access

Genital Herpes Simplex Virus Type 2 Infection in Humanized HIV-Transgenic Mice Triggers HIV Shedding and Is Associated With Greater Neurological Disease

Author(s) -

Briana G. Nixon,

Esra Fakioglu,

Martha Stefanidou,

Yingying Wang,

Mousumi Dutta,

HARRIS GOLDSTEIN,

Betsy C. Herold

Publication year - 2013

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1093/infdis/jit472

Subject(s) - herpes simplex virus , virology , immunology , biology , coinfection , virus , viral load , vesicular stomatitis virus , genetically modified mouse , transgene , biochemistry , gene

Epidemiological studies consistently demonstrate synergy between herpes simplex virus type 2 (HSV-2) and human immunodeficiency virus type 1 (HIV-1). Higher HIV-1 loads are observed in coinfected individuals, and conversely, HIV-1 is associated with more-severe herpetic disease. A small animal model of coinfection would facilitate identification of the biological mechanisms underlying this synergy and provide the opportunity to evaluate interventions.

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