Open AccessGene-Silencing Antisense Oligomers Inhibit Acinetobacter Growth In Vitro and In Vivo
Author(s) -
Bruce L. Geller,
Kimberly R. MarshallBatty,
Fred Schnell,
M. M. McKnight,
Patrick L. Iversen,
David E. Greenberg
Publication year - 2013
Publication title -
the journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.69
H-Index - 252
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1093/infdis/jit460
Subject(s) - in vivo , in vitro , gene silencing , microbiology and biotechnology , biology , gene , acinetobacter , virology , chemistry , antibiotics , genetics
Peptide-conjugated phosphorodiamidate morpholino oligomers (PPMOs) are synthetic DNA/RNA analogues that silence expression of specific genes. We studied whether PPMOs targeted to essential genes in Acinetobacter lwoffii and Acinetobacter baumannii are active in vitro and in vivo.
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