Increase in 2–Long Terminal Repeat Circles and Decrease in D-dimer After Raltegravir Intensification in Patients With Treated HIV Infection: A Randomized, Placebo-Controlled Trial | Zendy

Hiroyu Hatano | Zendy; Matthew C. Strain | Zendy; Rebecca Scherzer | Zendy; Peter Bacchetti | Zendy; Deborah Wentworth | Zendy; Rebecca Hoh | Zendy; Jeffrey N. Martin | Zendy; Joseph M. McCune | Zendy; James D. Neaton | Zendy; Russell P. Tracy | Zendy; Priscilla Y. Hsue | Zendy; Douglas D. Richman | Zendy; Steven G. Deeks | Zendy

Open Access

Increase in 2–Long Terminal Repeat Circles and Decrease in D-dimer After Raltegravir Intensification in Patients With Treated HIV Infection: A Randomized, Placebo-Controlled Trial

Author(s) -

Hiroyu Hatano,

Matthew C. Strain,

Rebecca Scherzer,

Peter Bacchetti,

Deborah Wentworth,

Rebecca Hoh,

Jeffrey N. Martin,

Joseph M. McCune,

James D. Neaton,

Russell P. Tracy,

Priscilla Y. Hsue,

Douglas D. Richman,

Steven G. Deeks

Publication year - 2013

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1093/infdis/jit453

Subject(s) - raltegravir , placebo , medicine , viral load , randomized controlled trial , gastroenterology , placebo controlled study , virology , human immunodeficiency virus (hiv) , immunology , antiretroviral therapy , double blind , pathology , alternative medicine

The degree to which human immunodeficiency virus (HIV) continues to replicate during antiretroviral therapy (ART) is controversial. We conducted a randomized, double-blind, placebo-controlled study to assess whether raltegravir intensification reduces low-level viral replication, as defined by an increase in the level of 2-long terminal repeat (2-LTR) circles.

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