A Shorter Time Interval Between First and Second Dengue Infections Is Associated With Protection From Clinical Illness in a School-based Cohort in Thailand
Author(s) -
Kathryn B. Anderson,
Robert V. Gibbons,
Derek A. T. Cummings,
Ananda Nisalak,
Sharone Green,
Daniel H. Libraty,
Richard G. Jarman,
A Srikiatkhachorn,
Mammen P. Mammen,
Darunee Buddhari,
In-Kyu Yoon,
Timothy P. Endy
Publication year - 2013
Publication title -
the journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.69
H-Index - 252
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1093/infdis/jit436
Subject(s) - dengue fever , subclinical infection , dengue virus , medicine , cohort , immunology , virology , cohort study , antibody
Despite the strong association between secondary dengue virus (DENV) infections and dengue hemorrhagic fever (DHF), the majority of secondary infections are subclinical or mild. The determinants of clinical severity remain unclear, though studies indicate a titer-dependent and time-dependent role of cross-protective anti-DENV antibodies.
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