Cryptococcus neoformans Ex Vivo Capsule Size Is Associated With Intracranial Pressure and Host Immune Response in HIV-associated Cryptococcal Meningitis | Zendy

Emma J. Robertson | Zendy; Grace Najjuka | Zendy; Melissa A. Rolfes | Zendy; Andrew Akampurira | Zendy; Neena Jain | Zendy; Janani Anantharanjit | Zendy; Maximilian von Hohenberg | Zendy; Manlio Tassieri | Zendy; Allan Carlsson | Zendy; David B. Meya | Zendy; Thomas S. Harrison | Zendy; Bettina C. Fries | Zendy; David R. Boulware | Zendy; Tihana Bicanic | Zendy

Open Access

Cryptococcus neoformans Ex Vivo Capsule Size Is Associated With Intracranial Pressure and Host Immune Response in HIV-associated Cryptococcal Meningitis

Author(s) -

Emma J. Robertson,

Grace Najjuka,

Melissa A. Rolfes,

Andrew Akampurira,

Neena Jain,

Janani Anantharanjit,

Maximilian von Hohenberg,

Manlio Tassieri,

Allan Carlsson,

David B. Meya,

Thomas S. Harrison,

Bettina C. Fries,

David R. Boulware,

Tihana Bicanic

Publication year - 2013

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1093/infdis/jit435

Subject(s) - cryptococcus neoformans , cryptococcosis , cryptococcal meningitis , ex vivo , immune system , meningitis , cryptococcus , immunology , microbiology and biotechnology , biology , aids related opportunistic infections , virology , human immunodeficiency virus (hiv) , in vivo , medicine , sida , viral disease , psychiatry

The Cryptococcus neoformans polysaccharide capsule is a well-characterized virulence factor with immunomodulatory properties. The organism and/or shed capsule is postulated to raise intracranial pressure (ICP) in cryptococcal meningitis (CM) by mechanical obstruction of cerebrospinal fluid (CSF) outflow. Little is known regarding capsule phenotype in human cryptococcosis. We investigated the relationship of ex vivo CSF capsular phenotype with ICP and CSF immune response, as well as in vitro phenotype.

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