Open AccessVirologic Correlates of Anti-CMV IgG Levels in HIV-1–Infected Men
Author(s) -
Sara Gianella,
Sheldon Morris,
Erick T. Tatro,
Milenka V. Vargas,
Richard Haubrich,
Eric S. Daar,
Michael P. Dubé,
Douglas D. Richman,
Susan J. Little,
Davey M. Smith
Publication year - 2013
Publication title -
the journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.69
H-Index - 252
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1093/infdis/jit434
Subject(s) - cytomegalovirus , immunology , immune system , antibody , peripheral blood mononuclear cell , virology , immunoglobulin g , medicine , human cytomegalovirus , immunopathology , virus , betaherpesvirinae , viral disease , herpesviridae , biology , in vitro , biochemistry
In human immunodeficiency virus (HIV)-infected individuals, higher levels of anti-cytomegalovirus (CMV) immunoglobulin G (IgG) antibody have been associated with increased immune activation, increased HIV transmission, cardiovascular complications, and neurocognitive impairment. However, the mechanism of these observations is unknown. This analysis of 228 HIV-infected men found that higher CMV IgG levels were positively associated with older age and antiretroviral treatment. Higher frequency of detectable CMV in peripheral blood mononuclear cells and recurrent seminal CMV reactivations were associated with lower plasma CMV IgG levels, suggesting that immune response to CMV rather than direct effect of viral replication is likely responsible for adverse clinical outcome observed in other studies.
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