Association of the IFNL4-ΔG Allele With Impaired Spontaneous Clearance of Hepatitis C Virus | Zendy

Peter Aka | Zendy; Mark H. Kuniholm | Zendy; Ruth M. Pfeiffer | Zendy; Alan S. Wang | Zendy; Wei Tang | Zendy; Sabrina Chen | Zendy; Jacquie Astemborski | Zendy; Michael Plankey | Zendy; Maria C. Villacres | Zendy; Marion G. Peters | Zendy; Seema Desai | Zendy; Eric C. Seaberg | Zendy; Brian R. Edlin | Zendy; Howard D. Strickler | Zendy; David L. Thomas | Zendy; Ludmila ProkuninaOlsson | Zendy; Gerald B. Sharp | Zendy; Thomas R. OʼBrien | Zendy

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Association of the IFNL4-ΔG Allele With Impaired Spontaneous Clearance of Hepatitis C Virus

Author(s) -

Peter Aka,

Mark H. Kuniholm,

Ruth M. Pfeiffer,

Alan S. Wang,

Wei Tang,

Sabrina Chen,

Jacquie Astemborski,

Michael Plankey,

Maria C. Villacres,

Marion G. Peters,

Seema Desai,

Eric C. Seaberg,

Brian R. Edlin,

Howard D. Strickler,

David L. Thomas,

Ludmila ProkuninaOlsson,

Gerald B. Sharp,

Thomas R. OʼBrien

Publication year - 2013

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1093/infdis/jit433

Subject(s) - medicine , odds ratio , virology , genotype , hepatitis c virus , hepatitis b virus , gastroenterology , virus , genetics , biology , gene

Interferon lambda 4 protein can be generated in IFNL4-ΔG carriers but not IFNL4-TT homozygotes. We studied 890 anti-hepatitis C virus (HCV)-positive participants in the Women's Interagency HIV Study. Among blacks (n = 555), HCV was more often cleared for those with genotype IFNL4-TT/TT (32.6%; odds ratio [OR], 3.59; P = 3.3 × 10(-5)) than IFNL4-TT/ΔG (11.3%; OR, 0.95; P = .86) or IFNL4-ΔG/ΔG (11.9%; referent). Pooling these data with published results in blacks (n = 1678), ORs were 3.84 (P = 8.6 × 10(-14)) for IFNL4-TT/TT and 1.44 (P = .03) IFNL4-TT/ΔG, and the area under the curve was 0.64 for IFNL4-ΔG genotype and 0.61 for rs12979860 (IL28B). IFNL4-ΔG is strongly associated with impaired spontaneous HCV clearance.

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