Importance of Toxin A, Toxin B, and CDT in Virulence of an Epidemic Clostridium difficile Strain | Zendy

Sarah A. Kuehne | Zendy; Mark M. Collery | Zendy; Michelle L. Kelly | Zendy; Stephen T. Cartman | Zendy; Alan Cockayne | Zendy; Nigel P. Minton | Zendy

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Importance of Toxin A, Toxin B, and CDT in Virulence of an Epidemic Clostridium difficile Strain

Author(s) -

Sarah A. Kuehne,

Mark M. Collery,

Michelle L. Kelly,

Stephen T. Cartman,

Alan Cockayne,

Nigel P. Minton

Publication year - 2013

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1093/infdis/jit426

Subject(s) - virulence , toxin , microbiology and biotechnology , clostridium difficile , clostridium difficile toxin a , clostridium difficile toxin b , biology , fulminant , virology , strain (injury) , antibiotics , immunology , gene , genetics , anatomy

Clostridium difficile infection is the main cause of healthcare-acquired diarrhea in the developed world. In addition to the main virulence factors toxin A and B, epidemic, PCR Ribotype 027 strains, such as R20291, produce a third toxin, CDT. To develop effective medical countermeasures, it is important to understand the importance of each toxin. Accordingly, we created all possible combinations of isogenic toxin mutants of R20291 and assessed their virulence. We demonstrated that either toxin A or toxin B alone can cause fulminant disease in the hamster infection model and present tantalizing data that C. difficile toxin may also contribute to virulence.

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