Ordered Accumulation of Mutations Conferring Resistance to Sulfadoxine-Pyrimethamine in the Plasmodium falciparum Parasite | Zendy

Toshihiro Mita | Zendy; Jun Ohashi | Zendy; Meera Venkatesan | Zendy; Aung Swi Prue Marma | Zendy; Masatoshi Nakamura | Zendy; Christopher V. Plowe | Zendy; Kazuyuki Tanabe | Zendy

Open Access

Ordered Accumulation of Mutations Conferring Resistance to Sulfadoxine-Pyrimethamine in the Plasmodium falciparum Parasite

Author(s) -

Toshihiro Mita,

Jun Ohashi,

Meera Venkatesan,

Aung Swi Prue Marma,

Masatoshi Nakamura,

Christopher V. Plowe,

Kazuyuki Tanabe

Publication year - 2013

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1093/infdis/jit415

Subject(s) - dhps , dihydropteroate synthase , dihydrofolate reductase , plasmodium falciparum , antifolate , sulfadoxine , biology , pyrimethamine , malaria , genetics , drug resistance , mutation , virology , gene , immunology , antimetabolite , chemotherapy

Monitoring the prevalence of drug resistant Plasmodium falciparum is essential for effective malaria control. Resistance to pyrimethamine and sulfadoxine increases as mutations accumulate in the parasite genes encoding dihydrofolate reductase (dhfr) and dihydropteroate synthase (dhps), respectively. Although parasites are exposed to these antifolate drugs simultaneously, it remains virtually unknown whether dhfr and dhps mutations accumulate along interrelated paths.

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