Open AccessClinical Factors That Predict Noncirrhotic Portal Hypertension in HIV-Infected Patients: A Proposed Diagnostic Algorithm
Author(s) -
Neehar D. Parikh,
Valérie MartelLaferrière,
Tatyana Kushner,
K. Childs,
Marie-Louise Vachon,
Deepti Dronamraju,
Chris Taylor,
Maria Isabel Fiel,
T. Schiano,
Mark Nelson,
Kosh Agarwal,
Douglas T. Dieterich
Publication year - 2013
Publication title -
the journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.69
H-Index - 252
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1093/infdis/jit412
Subject(s) - didanosine , medicine , algorithm , human immunodeficiency virus (hiv) , portal hypertension , retrospective cohort study , gastroenterology , hiv diagnosis , viral load , cohort , immunology , antiretroviral therapy , cirrhosis , computer science
Noncirrhotic portal hypertension (NCPH) is a rare but important clinical entity in human immunodeficiency virus (HIV) populations. The purpose of this study was to describe the clinical factors associated with the condition in an effort to formulate a diagnostic algorithm for easy and early diagnosis. We performed a multicenter, retrospective case-control study of 34 patients with NCPH and 68 control HIV patients. The study found that thrombocytopenia, splenomegaly, didanosine use, elevated aminotransferases, and an elevated alkaline phosphatase level were all significantly more prevalent in the NCPH cohort. Using these easily available clinical parameters, we developed an algorithm for early diagnosis of NCPH in HIV.
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