Phagocytic Dysfunction of Human Alveolar Macrophages and Severity of Chronic Obstructive Pulmonary Disease | Zendy

Charles S. Berenson | Zendy; Ragina L. Kruzel | Zendy; Ellana Eberhardt | Zendy; Sanjay Sethi | Zendy

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Phagocytic Dysfunction of Human Alveolar Macrophages and Severity of Chronic Obstructive Pulmonary Disease

Author(s) -

Charles S. Berenson,

Ragina L. Kruzel,

Ellana Eberhardt,

Sanjay Sethi

Publication year - 2013

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1093/infdis/jit400

Subject(s) - pulmonary disease , medicine , immunology , phagocytosis , chronic granulomatous disease , disease , pathology

Alveolar macrophages in chronic obstructive pulmonary disease (COPD) have fundamental impairment of phagocytosis for nontypeable Haemophilus influenzae (NTHI). However, relative selectivity of dysfunctional phagocytosis among diverse respiratory pathogens: NTHI, Moraxella catarrhalis (MC), Streptococcus pneumoniae (SP), and nonbacterial particles, as well as the contribution of impaired phagocytosis to severity of COPD, has not been explored.

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