Open AccessGreater Preexisting Interferon Responses to Mycobacterial Antigens and Lower Bacillary Load During HIV-Associated Tuberculosis
Author(s) -
Tim Lahey,
T. Czechura,
S.A. Crabtree,
R. D. Arbeit,
Mecky Matee,
C. Robert Horsburgh,
Todd A. MacKenzie,
M Bakari,
Kisali Pallangyo,
C. Fordham von Reyn
Publication year - 2013
Publication title -
the journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.69
H-Index - 252
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1093/infdis/jit396
Subject(s) - tuberculosis , mycobacterium tuberculosis , sputum , immunology , medicine , antigen , sputum culture , virology , tuberculosis diagnosis , pathology
The role of preexisting interferon (IFN) γ responses in controlling bacillary burden in human immunodeficiency virus (HIV)-associated tuberculosis is not known. Among BCG-immunized HIV-infected adults who developed tuberculosis in a phase III trial of an investigational tuberculosis vaccine, greater baseline IFN-γ responses to early secretory antigenic target 6 and Mycobacterium tuberculosis whole-cell lysate were associated with reduced bacillary burden on sputum smear grade, days to culture positivity on agar, and sputum culture grade during subsequent tuberculosis. This association was most consistent among recipients of the investigational vaccine. When HIV-associated tuberculosis develops, greater preexisting IFN-γ responses to mycobacterial antigens are associated with reduced tuberculosis bacillary burden. ClinicalTrials.gov Identifier. NCT0052195.
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