Klebsiella pneumoniae Peptidoglycan-Associated Lipoprotein and Murein Lipoprotein Contribute to Serum Resistance, Antiphagocytosis, and Proinflammatory Cytokine Stimulation | Zendy

PingHan Hsieh | Zendy; J.-Y. Liu | Zendy; YiJiun Pan | Zendy; M.-C. Wu | Zendy; TingSyuan Lin | Zendy; YuTsung Huang | Zendy; JannTay Wang | Zendy

Open Access

Klebsiella pneumoniae Peptidoglycan-Associated Lipoprotein and Murein Lipoprotein Contribute to Serum Resistance, Antiphagocytosis, and Proinflammatory Cytokine Stimulation

Author(s) -

PingHan Hsieh,

J.-Y. Liu,

YiJiun Pan,

M.-C. Wu,

TingSyuan Lin,

YuTsung Huang,

JannTay Wang

Publication year - 2013

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1093/infdis/jit384

Subject(s) - peptidoglycan , proinflammatory cytokine , klebsiella pneumoniae , microbiology and biotechnology , lipoprotein , biology , stimulation , immunology , bacteria , cholesterol , inflammation , endocrinology , biochemistry , escherichia coli , gene , genetics

Peptidoglycan-associated lipoprotein (Pal), murein lipoprotein (LppA), and outer membrane protein A (OmpA) are dominant outer membrane proteins (OMPs) that are released by gram-negative bacteria during sepsis. OMPs are implicated in the maintenance of cell envelope integrity. Here, we characterize the roles of these OMPs in pathogenesis during bacteremia caused by Klebsiella pneumoniae.

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