Emergence of New Pandemic GII.4 Sydney Norovirus Strain Correlates With Escape From Herd Immunity | Zendy

Kari Debbink | Zendy; Lisa C. Lindesmith | Zendy; Eric Donaldson | Zendy; Verónica Costantini | Zendy; Martina Beltramello | Zendy; Davide Corti | Zendy; Jesica Swanstrom | Zendy; Antonio Lanzavecchia | Zendy; Jan Vinjé | Zendy; Ralph S. Baric | Zendy

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Emergence of New Pandemic GII.4 Sydney Norovirus Strain Correlates With Escape From Herd Immunity

Author(s) -

Kari Debbink,

Lisa C. Lindesmith,

Eric Donaldson,

Verónica Costantini,

Martina Beltramello,

Davide Corti,

Jesica Swanstrom,

Antonio Lanzavecchia,

Jan Vinjé,

Ralph S. Baric

Publication year - 2013

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1093/infdis/jit370

Subject(s) - virology , epitope , norovirus , neutralization , polyclonal antibodies , outbreak , biology , pandemic , monoclonal antibody , antigen , immunity , blockade , virus , antibody , microbiology and biotechnology , medicine , immunology , disease , immune system , covid-19 , genetics , infectious disease (medical specialty) , receptor , pathology

GII.4 noroviruses are a significant source of acute gastroenteritis worldwide, causing the majority of human norovirus outbreaks. Evolution of the GII.4 major capsid protein occurs rapidly, resulting in the emergence of new strains that produce successive waves of pandemic disease. A new pandemic isolate, GII.4 2012 Sydney, largely replaced previously circulating strains in late 2012. We compare the antigenic properties of GII.4 2012 Sydney with previously circulating strains.

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