Hepatitis B Virus Infection Is Associated With Impaired Immunological Recovery During Antiretroviral Therapy in the Swiss HIV Cohort Study | Zendy

Gilles Wandeler | Zendy; Thomas Gsponer | Zendy; Florian Bihl | Zendy; Enos Bernasconi | Zendy; Matthias Cavassini | Zendy; Helen Kovari | Zendy; Patrick Schmid | Zendy; Manuel Battegay | Zendy; Alexandra Calmy | Zendy; Matthias Egger | Zendy; Hansjakob Furrer | Zendy; Andri Rauch | Zendy; Vincent Aubert | Zendy; Julia M. I. Barth | Zendy; J Böni | Zendy; Heiner C. Bucher | Zendy; Claudine BurtonJeangros | Zendy; Luigia Elzi | Zendy; Jan Fehr | Zendy; Jacques Fellay | Zendy; P Francioli | Zendy; Christoph A. Fux | Zendy; Meri Gorgievski | Zendy; H. Günthard | Zendy; David Haerry | Zendy; Barbara Hasse | Zendy; Hans H. Hirsch | Zendy; B Hirschel | Zendy; Irène Hösli | Zendy; Christian R. Kahlert | Zendy; Laurent Kaiser | Zendy; Olivia Keiser | Zendy; Christian Kind | Zendy; Thomas Klimkait | Zendy; Bruno Ledergerber | Zendy; G Martinetti | Zendy; Begoña Martínez de Tejada | Zendy; Karin J. Metzner | Zendy; Nora Müller | Zendy; David Nadal | Zendy; Giuseppe Pantaleo | Zendy; Stephan Regenass | Zendy; Martin Rickenbach | Zendy; C Rudin | Zendy; D. Schultze | Zendy; F. Schöni-Affolter | Zendy; Jörg Schüpbach | Zendy; René Speck | Zendy; Patrick Taffé | Zendy; Philip Tarr | Zendy; A. Telenti | Zendy; Alexandra Trkola | Zendy; P Vernazza | Zendy; Rachel Weber | Zendy; Sabine Yerly | Zendy

Open Access

Hepatitis B Virus Infection Is Associated With Impaired Immunological Recovery During Antiretroviral Therapy in the Swiss HIV Cohort Study

Author(s) -

Gilles Wandeler,

Thomas Gsponer,

Florian Bihl,

Enos Bernasconi,

Matthias Cavassini,

Helen Kovari,

Patrick Schmid,

Manuel Battegay,

Alexandra Calmy,

Matthias Egger,

Hansjakob Furrer,

Andri Rauch,

Vincent Aubert,

Julia M. I. Barth,

J Böni,

Heiner C. Bucher,

Claudine BurtonJeangros,

Luigia Elzi,

Jan Fehr,

Jacques Fellay,

P Francioli,

Christoph A. Fux,

Meri Gorgievski,

H. Günthard,

David Haerry,

Barbara Hasse,

Hans H. Hirsch,

B Hirschel,

Irène Hösli,

Christian R. Kahlert,

Laurent Kaiser,

Olivia Keiser,

Christian Kind,

Thomas Klimkait,

Bruno Ledergerber,

G Martinetti,

Begoña Martínez de Tejada,

Karin J. Metzner,

Nora Müller,

David Nadal,

Giuseppe Pantaleo,

Stephan Regenass,

Martin Rickenbach,

C Rudin,

D. Schultze,

F. Schöni-Affolter,

Jörg Schüpbach,

René Speck,

Patrick Taffé,

Philip Tarr,

A. Telenti,

Alexandra Trkola,

P Vernazza,

Rachel Weber,

Sabine Yerly

Publication year - 2013

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1093/infdis/jit351

Subject(s) - coinfection , medicine , hepatitis b virus , virology , immunology , hepatitis b , serology , cohort , viral disease , orthohepadnavirus , virus , hepadnaviridae , antibody

Hepatitis B virus (HBV) infection is a major cause of morbidity and mortality in human immunodeficiency virus (HIV)-infected patients worldwide. It is unclear whether HIV-related outcomes are affected by HBV coinfection. We compared virological suppression and immunological recovery during antiretroviral therapy (ART) of patients of different HBV serological status in the Swiss HIV Cohort Study. CD4 cell recovery during ART was significantly impaired in hepatitis B surface antigen-positive patients and in those with anti-hepatitis B core antigen alone compared with HBV-uninfected patients, despite similar virological efficacy of ART. CD4 increase in patients with resolved HBV infection was similar to that in HBV-uninfected individuals.

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