Acyclovir Prophylaxis Predisposes to Antiviral-Resistant Recurrent Herpetic Keratitis | Zendy

Monique van Velzen | Zendy; David van de Vijver | Zendy; Freek B. van Loenen | Zendy; Albert D. M. E. Osterhaus | Zendy; Lies Remeijer | Zendy; Georges M. G. M. Verjans | Zendy

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Acyclovir Prophylaxis Predisposes to Antiviral-Resistant Recurrent Herpetic Keratitis

Author(s) -

Monique van Velzen,

David van de Vijver,

Freek B. van Loenen,

Albert D. M. E. Osterhaus,

Lies Remeijer,

Georges M. G. M. Verjans

Publication year - 2013

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1093/infdis/jit350

Subject(s) - medicine , herpes simplex virus , odds ratio , keratitis , aciclovir , refractory (planetary science) , confidence interval , virology , gastroenterology , virus , dermatology , viral disease , herpesviridae , biology , astrobiology

Long-term acyclovir (ACV) prophylaxis, recommended to prevent recurrent herpes simplex virus type 1 (HSV-1) ocular disorders, may pose a risk for ACV-refractory disease due to ACV resistance. We determined the effect of ACV prophylaxis on the prevalence of corneal ACV-resistant (ACV(R)) HSV-1 and clinical consequences thereof in patients with recurrent HSV-1 keratitis (rHK).

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