Restoration of Type I Interferon Expression by Heme and Related Tetrapyrroles Through Inhibition of NS3/4A Protease | Zendy

Zhaowen Zhu | Zendy; M. Meleah Mathahs | Zendy; Warren N. Schmidt | Zendy

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Restoration of Type I Interferon Expression by Heme and Related Tetrapyrroles Through Inhibition of NS3/4A Protease

Author(s) -

Zhaowen Zhu,

M. Meleah Mathahs,

Warren N. Schmidt

Publication year - 2013

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1093/infdis/jit338

Subject(s) - ns3 , protease , biology , interferon , hepatitis c virus , ns2 3 protease , virology , biochemistry , virus , enzyme

Tetrapyrrole substrates and products of heme oxygenase are potent inhibitors of hepatitis C virus (HCV) replication. It is not clear whether this occurs through primary induction of type I interferon (IFN), inhibition of viral NS3/4A protease, or a combination of these mechanisms. We studied the antiviral actions of tetrapyrroles and their potential influence on type I IFN induction.

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