Daily Acyclovir to Decrease Herpes Simplex Virus Type 2 (HSV-2) Transmission from HSV-2/HIV-1 Coinfected Persons: A Randomized Controlled Trial | Zendy

Andrew Mujugira | Zendy; Amalia Magaret | Zendy; Connie Celum | Zendy; Jared M. Baeten | Zendy; Jairam R. Lingappa | Zendy; Rhoda Ashley Morrow | Zendy; Kenneth H. Fife | Zendy; Sinead DelanyMoretlwe | Zendy; Guy de Bruyn | Zendy; Elizabeth A. Bukusi | Zendy; Etienne Karita | Zendy; Saidi Kapiga | Zendy; Lawrence Corey | Zendy; Anna Wald | Zendy; Mary S. Campbell | Zendy; Robert W. Coombs | Zendy; James P. Hughes | Zendy; M. Juliana McElrath | Zendy; James I. Mullins | Zendy; David Coetzee | Zendy; Edwin Were | Zendy; Max Essex | Zendy; Joseph Makhema | Zendy; Elly Katabira | Zendy; Allan Ronald | Zendy; Kayitesi Kayitenkore | Zendy; Craig Cohen | Zendy; William Kanweka | Zendy; Susan Allen | Zendy; Bellington Vwalika | Zendy; Rachel Magi | Zendy; Carey Farquhar | Zendy; Grace JohnStewart | Zendy; James Kiarie | Zendy; Mubiana Inambao | Zendy; Orange Farm | Zendy; Helen Rees | Zendy; Glenda Gray | Zendy; James McIntyre | Zendy; Nelly Mugo | Zendy

Open Access

Daily Acyclovir to Decrease Herpes Simplex Virus Type 2 (HSV-2) Transmission from HSV-2/HIV-1 Coinfected Persons: A Randomized Controlled Trial

Author(s) -

Andrew Mujugira,

Amalia Magaret,

Connie Celum,

Jared M. Baeten,

Jairam R. Lingappa,

Rhoda Ashley Morrow,

Kenneth H. Fife,

Sinead DelanyMoretlwe,

Guy de Bruyn,

Elizabeth A. Bukusi,

Etienne Karita,

Saidi Kapiga,

Lawrence Corey,

Anna Wald,

Mary S. Campbell,

Robert W. Coombs,

James P. Hughes,

M. Juliana McElrath,

James I. Mullins,

David Coetzee,

Edwin Were,

Max Essex,

Joseph Makhema,

Elly Katabira,

Allan Ronald,

Kayitesi Kayitenkore,

Craig Cohen,

William Kanweka,

Susan Allen,

Bellington Vwalika,

Rachel Magi,

Carey Farquhar,

Grace JohnStewart,

James Kiarie,

Mubiana Inambao,

Orange Farm,

Helen Rees,

Glenda Gray,

James McIntyre,

Nelly Mugo

Publication year - 2013

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1093/infdis/jit333

Subject(s) - serodiscordant , medicine , herpes simplex virus , placebo , transmission (telecommunications) , virology , hazard ratio , immunology , viral load , confidence interval , virus , alternative medicine , pathology , antiretroviral therapy , electrical engineering , engineering

Daily suppressive therapy with valacyclovir reduces risk of sexual transmission of herpes simplex virus type 2 (HSV-2) in HSV-2-serodiscordant heterosexual couples by 48%. Whether suppressive therapy reduces HSV-2 transmission from persons coinfected with HSV-2 and human immunodeficiency virus type 1 (HIV-1) is unknown.

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