Noninvasive Molecular Imaging of Tuberculosis-Associated Inflammation With Radioiodinated DPA-713 | Zendy

Catherine A. Foss | Zendy; Jamie Harper | Zendy; Haofan Wang | Zendy; Martin G. Pomper | Zendy; Sanjay K. Jain | Zendy

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Noninvasive Molecular Imaging of Tuberculosis-Associated Inflammation With Radioiodinated DPA-713

Author(s) -

Catherine A. Foss,

Jamie Harper,

Haofan Wang,

Martin G. Pomper,

Sanjay K. Jain

Publication year - 2013

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1093/infdis/jit331

Subject(s) - translocator protein , inflammation , macrophage , in vivo , tuberculosis , pathology , ligand (biochemistry) , chemistry , medicine , immunology , biology , microglia , biochemistry , in vitro , receptor , microbiology and biotechnology

Increased expression of translocator protein (TSPO) is a feature of microglial and macrophage activation. Since activated macrophages are key components of tuberculosis-associated inflammation, we evaluated radioiodinated DPA-713, a synthetic ligand of TSPO, for in vivo imaging of host response.

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