English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Several recent high-profile studies have highlighted the potential impact of antiretroviral therapy (ART) initiation during acute human immunodeficiency virus type 1 (HIV-1) infection on viral reservoirs and persistence. Exciting observations presented at this year’s “Conference on Retroviruses and Opportunistic Infections” [1] on a child in Mississippi that started ART within hours of birth to an infected mother suggested that immediate treatment prevented HIV-1 from establishing a foothold in the infant, leading to lack of viral rebound after ART cessation. Two additional studies suggested that initiating early ART in adults with acute HIV-1 infection might limit seeding of key viral reservoirs, including those found in specific types of memory CD4 T cells [2–4]. Although the long-term significance of the observations in these provocative reports is not yet known, they have invigorated the field of HIV-1 curative strategies and persistence research. In this issue of The Journal of Infectious Diseases, 2 articles add to the growing discussion regarding the impact of early ART on reservoir size and T-cell activation, and help elucidate the composition of the HIV-1 reservoir in CD4 T-cell subsets in blood and gastrointestinal tissue.

Early Treatment and HIV-1 Reservoirs: A Stitch in Time?