Role of Interleukin 23 Signaling in Clostridium difficile Colitis | Zendy

Erica L. Buonomo | Zendy; Rajat Madan | Zendy; Patcharin Pramoonjago | Zendy; Li L | Zendy; Mark D. Okusa | Zendy; William A. Petri | Zendy

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Role of Interleukin 23 Signaling in Clostridium difficile Colitis

Author(s) -

Erica L. Buonomo,

Rajat Madan,

Patcharin Pramoonjago,

Li L,

Mark D. Okusa,

William A. Petri

Publication year - 2013

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1093/infdis/jit277

Subject(s) - clostridium difficile , colitis , immunology , microbiology and biotechnology , clostridium , interleukin 22 , interleukin , clostridium difficile colitis , biology , medicine , cytokine , antibiotics , bacteria , genetics

Clostridium difficile is currently the leading cause of hospital-acquired infections in the United States. Here, we observed increased interleukin 23 (IL-23) protein levels in human colon biopsy specimens positive for C. difficile toxins, compared with levels in negative controls (P = .008) We also investigated the role of IL-23 during C. difficile infection, using 2 distinct murine models. Mice lacking IL-23 signaling had a significant increase in survival (100% [12 mice]), compared with control mice (16.7%-50% [12 mice]). These data suggest a new potential drug target for human C. difficile treatment and indicate the first link between IL-23 and disease severity during murine infection.

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