Occupational Exposure to Hepatitis C Virus: Early T-Cell Responses in the Absence of Seroconversion in a Longitudinal Cohort Study | Zendy

Theo Heller | Zendy; Jens Werner | Zendy; Fareed Rahman | Zendy; Eishiro Mizukoshi | Zendy; Yuji Sobao | Zendy; Ann Marie Gordon | Zendy; Arlene Sheets | Zendy; Averell H. Sherker | Zendy; E. Richard Kessler | Zendy; Kathleen S. Bean | Zendy; Steven K. Herrine | Zendy; M'Lou Stevens | Zendy; J Schmitt | Zendy; Barbara Rehermann | Zendy

Open Access

Occupational Exposure to Hepatitis C Virus: Early T-Cell Responses in the Absence of Seroconversion in a Longitudinal Cohort Study

Author(s) -

Theo Heller,

Jens Werner,

Fareed Rahman,

Eishiro Mizukoshi,

Yuji Sobao,

Ann Marie Gordon,

Arlene Sheets,

Averell H. Sherker,

E. Richard Kessler,

Kathleen S. Bean,

Steven K. Herrine,

M'Lou Stevens,

J Schmitt,

Barbara Rehermann

Publication year - 2013

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1093/infdis/jit270

Subject(s) - seroconversion , medicine , hepatitis c virus , virology , immunology , cohort , viral disease , hepatitis c , virus , hepatitis a virus , antibody , flaviviridae , cohort study

T-cell responses have been described in seronegative patients who test negative for hepatitis C virus (HCV) RNA despite frequent HCV exposure. However, the cross-sectional design of those studies did not clarify whether T cells were indeed induced by low-level HCV exposure without seroconversion or whether they resulted from regular acute infection with subsequent antibody loss.

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