Higher Expression of Several Interferon-Stimulated Genes in HIV-1-Infected Females After Adjusting for the Level of Viral Replication | Zendy

J. Judy Chang | Zendy; Matt Woods | Zendy; Robert Lindsay | Zendy; Erin Doyle | Zendy; Morgane Griesbeck | Zendy; Ellen S. Chan | Zendy; Gregory K. Robbins | Zendy; Ronald J. Bosch | Zendy; Marcus Altfeld | Zendy

Open Access

Higher Expression of Several Interferon-Stimulated Genes in HIV-1-Infected Females After Adjusting for the Level of Viral Replication

Author(s) -

J. Judy Chang,

Matt Woods,

Robert Lindsay,

Erin Doyle,

Morgane Griesbeck,

Ellen S. Chan,

Gregory K. Robbins,

Ronald J. Bosch,

Marcus Altfeld

Publication year - 2013

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1093/infdis/jit262

Subject(s) - interferon , viral replication , immune system , virology , biology , gene , virus , human immunodeficiency virus (hiv) , alpha interferon , lentivirus , immunology , viral disease , gene expression , immunopathology , replication (statistics) , genetics

Clinical studies have shown faster disease progression and stronger immune activation in human immunodeficiency virus (HIV)-1-infected females when compared with males for the same level of HIV-1 replication. Here we determine whether the elevated levels of HIV-1-induced interferon-alpha (IFN-α) production observed in females are associated with higher interferon-stimulated gene (ISG) expression levels in T cells, hence suggesting type-I IFN as a mechanism for the higher HIV-1-associated immune activation observed.

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