Disruption of Mycobactin Biosynthesis Leads to Attenuation of Mycobacterium tuberculosis for Growth and Virulence | Zendy

P. Vineel Reddy | Zendy; Rupangi Verma Puri | Zendy; Priyanka Chauhan | Zendy; Ritika Kar Bahal | Zendy; Akshay Rohilla | Zendy; Aparna Khera | Zendy; Anil K. Tyagi | Zendy

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Disruption of Mycobactin Biosynthesis Leads to Attenuation of Mycobacterium tuberculosis for Growth and Virulence

Author(s) -

P. Vineel Reddy,

Rupangi Verma Puri,

Priyanka Chauhan,

Ritika Kar Bahal,

Akshay Rohilla,

Aparna Khera,

Anil K. Tyagi

Publication year - 2013

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1093/infdis/jit250

Subject(s) - virulence , mycobacterium tuberculosis , microbiology and biotechnology , tuberculosis , biosynthesis , biology , virology , medicine , biochemistry , enzyme , pathology , gene

Low iron availability in the host upregulates the mbt gene cluster of Mycobacterium tuberculosis, which is responsible for mycobactin biosynthesis. However, the biological significance of mycobactins in the growth of this pathogen and in disease progression has not been elucidated.

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