Open AccessPopulation-Level Antibody Estimates to Novel Influenza A/H7N9
Author(s) -
Maciej F. Boni,
Nguyễn Văn Vĩnh Châu,
Nguyễn Thị Đông,
S. Rob Todd,
Nguyen Thi Duy Nhat,
Erwin de Bruin,
Janko van Beek,
Nguyễn Trần Hiển,
Cameron P. Simmons,
Jeremy Farrar,
Marion Koopmans
Publication year - 2013
Publication title -
the journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.69
H-Index - 252
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1093/infdis/jit224
Subject(s) - virology , titer , influenza a virus subtype h5n1 , virus , antibody titer , antibody , antigen , h5n1 genetic structure , population , biology , influenza a virus , antigenic drift , immunology , medicine , covid-19 , infectious disease (medical specialty) , disease , environmental health
There are no contemporary data available describing human immunity to novel influenza A/H7N9. Using 1723 prospectively collected serum samples in southern Vietnam, we tested for antibodies to 5 avian influenza virus antigens, using a protein microarray. General-population antibody titers against subtype H7 virus are higher than antibody titers against subtype H5 and lower than titers against H9. The highest titers were observed for human influenza virus subtypes. Titers to avian influenza virus antigens increased with age and with geometric mean antibody titer to human influenza virus antigens. There were no titer differences between the urban and the rural location in our study.
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