Prophylactic Efficacy of Oral Emtricitabine and Tenofovir Disoproxil Fumarate Combination Therapy Against a Tenofovir-Resistant Simian/Human Immunodeficiency Virus Containing the K65R Mutation in Macaques | Zendy

Mianer Cong | Zendy; James Mitchell | Zendy; Elizabeth Sweeney | Zendy; Sha Bachman | Zendy; Debra L. Hanson | Zendy; Walid Heneine | Zendy; J. Gerardo Garcı́a-Lerma | Zendy

Open Access

Prophylactic Efficacy of Oral Emtricitabine and Tenofovir Disoproxil Fumarate Combination Therapy Against a Tenofovir-Resistant Simian/Human Immunodeficiency Virus Containing the K65R Mutation in Macaques

Author(s) -

Mianer Cong,

James Mitchell,

Elizabeth Sweeney,

Sha Bachman,

Debra L. Hanson,

Walid Heneine,

J. Gerardo Garcı́a-Lerma

Publication year - 2013

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1093/infdis/jit189

Subject(s) - emtricitabine , simian immunodeficiency virus , virology , tenofovir , virus , medicine , simian , human immunodeficiency virus (hiv) , reverse transcriptase inhibitor , pharmacology , biology , viral load , sida , viral disease , antiretroviral therapy

Daily preexposure prophylaxis (PrEP) with emtricitabine/tenofovir disoproxil fumarate (FTC/TDF) is a novel strategy for preventing human immunodeficiency virus infection. We investigated in macaques whether FTC/TDF prevents transmission of a tenofovir-resistant simian/human immunodeficiency virus (SHIV) containing the K65R mutation. Six macaques received weekly a dose of FTC/TDF 3 days before rectal SHIV exposures and a second dose 2 hours after. Six untreated animals were controls. Animals were exposed rectally to escalating virus doses weekly for up to 28 weeks. PrEP significantly delayed infection with SHIVK65R (P = .028), although 4 of 6 FTC/TDF-treated macaques were infected at the end of the challenges. These findings highlight the need to closely monitor PrEP efficacy in areas with prevalent K65R.

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