tPA Alu (I/D) Polymorphism Associates With Bacterial Osteomyelitis | Zendy

Eulalia Valle-Garay | Zendy; A. Hugo Montes | Zendy; Jose R. Corte | Zendy; Álvaro Meana | Zendy; Joshua Fierer | Zendy; Víctor Asensi | Zendy

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tPA Alu (I/D) Polymorphism Associates With Bacterial Osteomyelitis

Author(s) -

Eulalia Valle-Garay,

A. Hugo Montes,

Jose R. Corte,

Álvaro Meana,

Joshua Fierer,

Víctor Asensi

Publication year - 2013

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1093/infdis/jit158

Subject(s) - osteomyelitis , fibrinolysis , genotype , medicine , immunology , tissue plasminogen activator , plasminogen activator inhibitor 1 , gastroenterology , plasminogen activator , biology , genetics , gene

Coagulation and fibrinolysis are important in infections and systemic inflammatory response syndrome. Polymorphisms in plasminogen activator inhibitor-1 (PAI-1, SERPINE1) and tissue plasminogen activator (tPA, PLAT), such as PAI-1 (-675 4G/5G deletion/insertion) and tPA (Alu insertion/deletion [I/D]), are associated with strokes, myocardial infarctions, bacterial infections and septic shock severity, and trauma. Osteomyelitis is a mostly posttraumatic, Staphylococcal bone infection.

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