Genotoxic Signature in Cord Blood Cells of Newborns Exposed In Utero to a Zidovudine-Based Antiretroviral Combination
Author(s) -
Isabelle AndréSchmutz,
Liliane DalCortivo,
Emmanuelle Six,
Sophie Kaltenbach,
Fabienne Cocchiarella,
Jérôme Le Chenadec,
Nicolas Cagnard,
AnneGaël Cordier,
Alexandra Benachi,
Laurent Mandelbrot,
Élie Azria,
Naïma Bouallag,
Sonia Luce,
Brigitte Ternaux,
C Reimann,
Patrick Revy,
I Radford-Weiss,
Cristina Leschi,
Alessandra Recchia,
Fulvio Mavilio,
Marina Cavazzana,
Stéphane Blanche
Publication year - 2013
Publication title -
the journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.69
H-Index - 252
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1093/infdis/jit149
Subject(s) - zidovudine , in utero , cord blood , medicine , virology , antiretroviral drug , immunology , biology , human immunodeficiency virus (hiv) , fetus , viral disease , pregnancy , viral load , antiretroviral therapy , genetics
The genotoxicity of zidovudine has been established in experimental models. The objective of the study was to identify genotoxicity markers in cord blood cells from newborns exposed in utero to antiretroviral (ARV) combinations containing zidovudine.
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