The Multiple Paths to Heteroresistance and Intermediate Resistance to Vancomycin in Staphylococcus aureus | Zendy

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The Multiple Paths to Heteroresistance and Intermediate Resistance to Vancomycin in Staphylococcus aureus

Author(s) -

Stan Deresinski

Publication year - 2013

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1093/infdis/jit136

Subject(s) - staphylococcus aureus , vancomycin , microbiology and biotechnology , medicine , methicillin resistant staphylococcus aureus , staphylococcal infections , drug resistance , biology , bacteria , genetics

identification of the detection of resistant mutants. With the appearance of the latter, daptomycin minimal inhibitory concentrations (MICs) rose, along with those of vancomycin, and this was accompanied by thickened cell walls and reduced autolysis, decreased surface anionic charge, and susceptibility to cationic peptides. Whole-genome sequencing demonstrated that the vancomycinintermediate S. aureus (VISA) phenotype was acquired via at least 3 different genetic pathways and that, in one of the 2 cases, the pathway differed from that seen in vivo. High-level resistance of S. aureus to vancomycin, resulting from horizontal

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