Mannose-Binding Lectin and Susceptibility to Schistosomiasis | Zendy

Justin S. Antony | Zendy; Olusola Ojurongbe | Zendy; Hoang Văn Tong | Zendy; Eman Abou Ouf | Zendy; Thomas Engleitner | Zendy; Akeem Abiodun Akindele | Zendy; Olawumi R. Sina-Agbaje | Zendy; A. O. Adeyeba | Zendy; Peter G. Kremsner | Zendy; Thirumalaisamy P. Velavan | Zendy

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Mannose-Binding Lectin and Susceptibility to Schistosomiasis

Author(s) -

Justin S. Antony,

Olusola Ojurongbe,

Hoang Văn Tong,

Eman Abou Ouf,

Thomas Engleitner,

Akeem Abiodun Akindele,

Olawumi R. Sina-Agbaje,

A. O. Adeyeba,

Peter G. Kremsner,

Thirumalaisamy P. Velavan

Publication year - 2013

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1093/infdis/jit081

Subject(s) - mannan binding lectin , schistosomiasis , lectin pathway , immunology , biology , complement system , schistosoma haematobium , lectin , genotype , haplotype , schistosoma mansoni , virology , genetics , antibody , alternative complement pathway , gene , helminths

Human ficolin 2 (encoded by FCN2) and mannose-binding lectin (encoded by MBL2) bind to specific pathogen-associated molecular patterns, activate the complement lectin cascade in a similar manner, and are associated with several infectious diseases. Our recently published study established certain FCN2 promoter variants and ficolin-2 serum levels as protective factors against schistosomiasis.

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