Regulation of Chemokines, CCL3 and CCL4, by Interferon γ and Nitric Oxide Synthase 2 in Mouse Macrophages and During Salmonella enterica Serovar Typhimurium Infection | Zendy

Bhagawat Chandrasekar | Zendy; Mukta DeobagkarLele | Zendy; Emmanuel StephenVictor | Zendy; Dipankar Nandi | Zendy

Open Access

Regulation of Chemokines, CCL3 and CCL4, by Interferon γ and Nitric Oxide Synthase 2 in Mouse Macrophages and During Salmonella enterica Serovar Typhimurium Infection

Author(s) -

Bhagawat Chandrasekar,

Mukta DeobagkarLele,

Emmanuel StephenVictor,

Dipankar Nandi

Publication year - 2013

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1093/infdis/jit067

Subject(s) - salmonella enterica , microbiology and biotechnology , ccl3 , nitric oxide synthase , salmonella , chemokine , serotype , biology , nitric oxide , interferon , virology , immunology , bacteria , immune system , ccl2 , endocrinology , genetics

Interferon γ (IFN-γ) increases the expression of multiple genes and responses; however, the mechanisms by which IFN-γ downmodulates cellular responses is not well understood. In this study, the repression of CCL3 and CCL4 by IFN-γ and nitric oxide synthase 2 (NOS2) in macrophages and upon Salmonella typhimurium infection of mice was investigated.

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