Sequence Analysis of Transplacentally Acquired Human Herpesvirus 6 DNA Is Consistent With Transmission of a Chromosomally Integrated Reactivated Virus | Zendy

Annie Gravel | Zendy; Caroline Breese Hall | Zendy; Louis Flamand | Zendy

Open Access

Sequence Analysis of Transplacentally Acquired Human Herpesvirus 6 DNA Is Consistent With Transmission of a Chromosomally Integrated Reactivated Virus

Author(s) -

Annie Gravel,

Caroline Breese Hall,

Louis Flamand

Publication year - 2013

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1093/infdis/jit060

Subject(s) - biology , virology , virus , transmission (telecommunications) , cord blood , gene , sequence analysis , sequence (biology) , herpesviridae , human herpesvirus 6 , genetics , dna , dna sequencing , viral disease , electrical engineering , engineering

The majority of human herpesvirus 6 (HHV-6) congenital infections (86%) originate from germ line transmission of chromosomally integrated HHV-6 (ciHHV-6). To determine whether transplacentally acquired HHV-6 could derive from the transmission of reactivated maternal ciHHV-6, we identified mother-infant pairs in which infants had proven transplacentally acquired HHV-6 and mothers had documented ciHHV-6, and we sequenced and compared the HHV-6 gB gene sequences for each pair. Our data indicate that the gB gene sequence found in each cord blood specimen was identical to that of the corresponding mother but divergent from that of other known HHV-6 isolates. These results are consistent with transplacentally acquired HHV-6 originating from the transmission of reactivated ciHHV-6.

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