Intestinal Epithelial Restitution After TcdB Challenge and Recovery From Clostridium difficile Infection in Mice With Alanyl-Glutamine Treatment | Zendy

Raphael Silva Rodrigues | Zendy; Renato A. C. Oliveira | Zendy; Yuesheng Li | Zendy; Snjezana ZajaMilatovic | Zendy; Lourrany Borges Costa | Zendy; Manuel B. Braga Neto | Zendy; Glynis L. Kolling | Zendy; Aldo Â. M. Lima | Zendy; Richard L. Guerrant | Zendy; Cirle A. Warren | Zendy

Open Access

Intestinal Epithelial Restitution After TcdB Challenge and Recovery From Clostridium difficile Infection in Mice With Alanyl-Glutamine Treatment

Author(s) -

Raphael Silva Rodrigues,

Renato A. C. Oliveira,

Yuesheng Li,

Snjezana ZajaMilatovic,

Lourrany Borges Costa,

Manuel B. Braga Neto,

Glynis L. Kolling,

Aldo Â. M. Lima,

Richard L. Guerrant,

Cirle A. Warren

Publication year - 2013

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1093/infdis/jit041

Subject(s) - clostridium difficile , microbiology and biotechnology , glutamine , restitution , clostridium difficile toxin a , c difficile , virology , biology , clostridium , immunology , medicine , antibiotics , bacteria , amino acid , biochemistry , genetics , political science , law

Clostridium difficile is an anaerobic bacterium that causes antibiotic-associated diarrhea. It produces toxin A and toxin B (TcdB), which cause injury to the gut epithelium. Glutamine is a fundamental fuel for enterocytes, maintaining intestinal mucosal health. Alanyl-glutamine (AQ) is a highly soluble dipeptide derivative of glutamine. We studied whether administration of AQ ameliorates the effects of TcdB in the intestinal cells and improves the outcome of C. difficile infection in mice.

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