Hepatitis C Virus Envelope Glycoprotein Signatures Are Associated With Treatment Failure and Modulation of Viral Entry and Neutralization
Author(s) -
Évelyne Schvoerer,
Rémy Moenne-Loccoz,
John M. Murray,
Aurélie Velay,
Marine Turek,
Isabel Fofana,
Samira FafiKremer,
Anne-Claire Erba,
François Habersetzer,
Michel Doffoël,
JeanPierre Gut,
Maureen J. Donlin,
John E. Tavis,
Mirjam B. Zeisel,
Françoise StollKeller,
Thomas F. Baumert
Publication year - 2013
Publication title -
the journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.69
H-Index - 252
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1093/infdis/jit032
Subject(s) - virology , glycoprotein , infectivity , hepatitis c virus , virus , neutralization , cd81 , antibody , viral envelope , biology , viral entry , hepacivirus , immunology , viral replication , microbiology and biotechnology
A major challenge for antiviral treatment of hepatitis C virus (HCV) infection is viral resistance, potentially resulting from the high variability of HCV envelope glycoproteins and subsequent selection of strains with enhanced infectivity and/or immune escape.
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