Leptin Mediates the Pathogenesis of Severe 2009 Pandemic Influenza A(H1N1) Infection Associated With Cytokine Dysregulation in Mice With Diet-Induced Obesity | Zendy

Jinxia Zhang | Zendy; Kelvin KaiWang To | Zendy; Can Li | Zendy; Candy C. Y. Lau | Zendy; Vincent KwokMan Poon | Zendy; Chris Chan | Zendy; BoJian Zheng | Zendy; Ivan FanNgai Hung | Zendy; Karen S.L. Lam | Zendy; Aimin Xu | Zendy; KwokYung Yuen | Zendy

Open Access

Leptin Mediates the Pathogenesis of Severe 2009 Pandemic Influenza A(H1N1) Infection Associated With Cytokine Dysregulation in Mice With Diet-Induced Obesity

Author(s) -

Jinxia Zhang,

Kelvin KaiWang To,

Can Li,

Candy C. Y. Lau,

Vincent KwokMan Poon,

Chris Chan,

BoJian Zheng,

Ivan FanNgai Hung,

Karen S.L. Lam,

Aimin Xu,

KwokYung Yuen

Publication year - 2013

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1093/infdis/jit031

Subject(s) - proinflammatory cytokine , leptin , immunology , pathogenesis , medicine , influenza a virus , cytokine , inflammation , endocrinology , obesity , virus

Obesity is associated with a high circulating leptin level and severe 2009 pandemic influenza A virus subtype H1N1 (A[H1N1]pdm09) infection. The mechanism for severe lung injury in obese patients and the specific treatment strategy remain elusive.

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