Open AccessQuantitative Assessment of Altered Rectal Mucosal Permeability Due to Rectally Applied Nonoxynol-9, Biopsy, and Simulated Intercourse
Author(s) -
Edward J. Fuchs,
Lisa A. Grohskopf,
Linda A. Lee,
Rahul P. Bakshi,
Craig W. Hendrix
Publication year - 2013
Publication title -
the journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.69
H-Index - 252
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1093/infdis/jit030
Subject(s) - microbicide , urine , medicine , dosing , confidence interval , toxicity , pharmacokinetics , human immunodeficiency virus (hiv) , immunology
Microbicide toxicity may reduce the efficacy of topical preexposure prophylaxis for human immunodeficiency virus (HIV) transmission. Noninvasive quantitative measures of microbicide toxicity would usefully inform microbicide development.
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