Impact of Antiretroviral Therapy Duration and Intensification on Isolated Shedding of HIV-1 RNA in Semen
Author(s) -
B. Osborne,
Prameet M. Sheth,
Tae Joon Yi,
Colin Kovacs,
Erika Benko,
Charles la Porte,
Sanja Huibner,
Anh Q. Le,
Ryan Danroth,
Bemuluyigza Baraki,
Tony Mazzulli,
Zabrina L. Brumme,
Rupert Kaul
Publication year - 2013
Publication title -
the journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.69
H-Index - 252
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1093/infdis/jit026
Subject(s) - semen , antiretroviral therapy , virology , human immunodeficiency virus (hiv) , medicine , lentivirus , viral shedding , viral load , immunology , biology , viral disease , andrology , virus
Effective antiretroviral therapy (ART) dramatically reduces human immunodeficiency virus (HIV) transmission. However, isolated shedding of HIV type 1 (HIV-1) in semen (IHS) can occur in the absence of detectable viremia or genital infections. We hypothesized that ART intensification with medications active in semen might prevent IHS.
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