Heterogeneity and Evolution of Thymidine Kinase and DNA Polymerase Mutants of Herpes Simplex Virus Type 1: Implications for Antiviral Therapy | Zendy

Graciela Andreï | Zendy; Aspasia Georgala | Zendy; Dimitri Topalis | Zendy; Pierre Fiten | Zendy; Michel Aoun | Zendy; Ghislain Opdenakker | Zendy; Robert Snoeck | Zendy

Open Access

Heterogeneity and Evolution of Thymidine Kinase and DNA Polymerase Mutants of Herpes Simplex Virus Type 1: Implications for Antiviral Therapy

Author(s) -

Graciela Andreï,

Aspasia Georgala,

Dimitri Topalis,

Pierre Fiten,

Michel Aoun,

Ghislain Opdenakker,

Robert Snoeck

Publication year - 2013

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1093/infdis/jit019

Subject(s) - biology , herpes simplex virus , virology , thymidine kinase , drug resistance , ganciclovir , virus , genotype , polymerase , dna polymerase , polymerase chain reaction , herpesviridae , viral disease , dna , microbiology and biotechnology , gene , human cytomegalovirus , genetics

Infections caused by acyclovir-resistant isolates of herpes simplex virus (HSV) after hematopoietic stem cell transplantation (HSCT) are an emerging concern. An understanding of the evolutionary aspects of HSV infection is crucial to the design of effective therapeutic and control strategies.

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