Human Immunodeficiency Viruses Appear Compartmentalized to the Female Genital Tract in Cross-Sectional Analyses but Genital Lineages Do Not Persist Over Time | Zendy

Marta E. Bull | Zendy; L. M. Heath | Zendy; Jennifer McKernan-Mullin | Zendy; Kelli Kraft | Zendy; Luis Acevedo | Zendy; Jane Hitti | Zendy; Susan E. Cohn | Zendy; Kenneth Tapia | Zendy; Sarah Holte | Zendy; Joan Dragavon | Zendy; Robert W. Coombs | Zendy; James I. Mullins | Zendy; Lisa M. Frenkel | Zendy

Open Access

Human Immunodeficiency Viruses Appear Compartmentalized to the Female Genital Tract in Cross-Sectional Analyses but Genital Lineages Do Not Persist Over Time

Author(s) -

Marta E. Bull,

L. M. Heath,

Jennifer McKernan-Mullin,

Kelli Kraft,

Luis Acevedo,

Jane Hitti,

Susan E. Cohn,

Kenneth Tapia,

Sarah Holte,

Joan Dragavon,

Robert W. Coombs,

James I. Mullins,

Lisa M. Frenkel

Publication year - 2013

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1093/infdis/jit016

Subject(s) - biology , sex organ , genital tract , clade , compartmentalization (fire protection) , virology , immunology , genetics , physiology , phylogenetics , gene , biochemistry , enzyme

Whether unique human immunodeficiency type 1 (HIV) genotypes occur in the genital tract is important for vaccine development and management of drug resistant viruses. Multiple cross-sectional studies suggest HIV is compartmentalized within the female genital tract. We hypothesize that bursts of HIV replication and/or proliferation of infected cells captured in cross-sectional analyses drive compartmentalization but over time genital-specific viral lineages do not form; rather viruses mix between genital tract and blood.

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