Plasma Viral Loads During Early HIV-1 Infection Are Similar in Subtype C– and Non-Subtype C–Infected African Seroconverters | Zendy

Mary S. Campbell | Zendy; Erin Kahle | Zendy; Connie Celum | Zendy; Jairam R. Lingappa | Zendy; Saidi Kapiga | Zendy; Andrew Mujugira | Zendy; Nelly Mugo | Zendy; Kenneth H. Fife | Zendy; James I. Mullins | Zendy; Jared M. Baeten | Zendy; Anna Wald | Zendy; Lawrence Corey | Zendy; Robert W. Coombs | Zendy; James P. Hughes | Zendy; Amalia Magaret | Zendy; M. Juliana McElrath | Zendy; Rhoda Morrow | Zendy; David Coetzee | Zendy; Edwin Were | Zendy; Max Essex | Zendy; Joseph Makhema | Zendy; Elly Katabira | Zendy; Allan Ronald | Zendy; Susan Allen | Zendy; Kayitesi Kayitenkore | Zendy; Etienne Karita | Zendy; Elizabeth A. Bukusi | Zendy; Craig Cohen | Zendy; William Kanweka | Zendy; Bellington Vwalika | Zendy; Rachel Magi | Zendy; Carey Farquhar | Zendy; Grace JohnStewart | Zendy; James Kiarie | Zendy; Mubiana Inambao | Zendy; Orange Farm | Zendy; Sinead DelanyMoretlwe | Zendy; Helen Rees | Zendy; Guy de Bruyn | Zendy; Glenda Gray | Zendy; James McIntyre | Zendy

Open Access

Plasma Viral Loads During Early HIV-1 Infection Are Similar in Subtype C– and Non-Subtype C–Infected African Seroconverters

Author(s) -

Mary S. Campbell,

Erin Kahle,

Connie Celum,

Jairam R. Lingappa,

Saidi Kapiga,

Andrew Mujugira,

Nelly Mugo,

Kenneth H. Fife,

James I. Mullins,

Jared M. Baeten,

Anna Wald,

Lawrence Corey,

Robert W. Coombs,

James P. Hughes,

Amalia Magaret,

M. Juliana McElrath,

Rhoda Morrow,

David Coetzee,

Edwin Were,

Max Essex,

Joseph Makhema,

Elly Katabira,

Allan Ronald,

Susan Allen,

Kayitesi Kayitenkore,

Etienne Karita,

Elizabeth A. Bukusi,

Craig Cohen,

William Kanweka,

Bellington Vwalika,

Rachel Magi,

Carey Farquhar,

Grace JohnStewart,

James Kiarie,

Mubiana Inambao,

Orange Farm,

Sinead DelanyMoretlwe,

Helen Rees,

Guy de Bruyn,

Glenda Gray,

James McIntyre

Publication year - 2013

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1093/infdis/jit015

Subject(s) - viremia , virology , viral load , biology , human immunodeficiency virus (hiv) , viral disease , immunology , lentivirus , setpoint , artificial intelligence , computer science

Recent data suggest that infection with human immunodeficiency virus type 1 (HIV-1) subtype C results in prolonged high-level viremia (>5 log10 copies/mL) during early infection. We examined the relationship between HIV-1 subtype and plasma viremia among 153 African seroconverters. Mean setpoint viral loads were similar for C and non-C subtypes: 4.36 vs 4.42 log10 copies/mL (P = .61). The proportion of subtype C-infected participants with viral loads >5 log10 copies/mL was not greater than the proportion for those with non-C infection. Our data do not support the hypothesis that higher early viral load accounts for the rapid spread of HIV-1 subtype C in southern Africa.

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