Inhibition of Telomerase Activity by Human Immunodeficiency Virus (HIV) Nucleos(t)ide Reverse Transcriptase Inhibitors: A Potential Factor Contributing to HIV-Associated Accelerated Aging | Zendy

Edwin Leeansyah | Zendy; Paul Cameron | Zendy; Ajantha Solomon | Zendy; Surekha Tennakoon | Zendy; Pushparaj Velayudham | Zendy; Maëlenn Gouillou | Zendy; Tim Spelman | Zendy; Anna C. Hearps | Zendy; Christopher K. Fairley | Zendy; De Villiers Smit | Zendy; Anna Pierce | Zendy; Jude Armishaw | Zendy; Suzanne M. Crowe | Zendy; David A. Cooper | Zendy; Kersten K. Koelsch | Zendy; JunPing Liu | Zendy; John Chuah | Zendy; Sharon R. Lewin | Zendy

Open Access

Inhibition of Telomerase Activity by Human Immunodeficiency Virus (HIV) Nucleos(t)ide Reverse Transcriptase Inhibitors: A Potential Factor Contributing to HIV-Associated Accelerated Aging

Author(s) -

Edwin Leeansyah,

Paul Cameron,

Ajantha Solomon,

Surekha Tennakoon,

Pushparaj Velayudham,

Maëlenn Gouillou,

Tim Spelman,

Anna C. Hearps,

Christopher K. Fairley,

De Villiers Smit,

Anna Pierce,

Jude Armishaw,

Suzanne M. Crowe,

David A. Cooper,

Kersten K. Koelsch,

JunPing Liu,

John Chuah,

Sharon R. Lewin

Publication year - 2013

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1093/infdis/jit006

Subject(s) - abacavir , telomerase , lamivudine , zidovudine , peripheral blood mononuclear cell , emtricitabine , reverse transcriptase , virology , reverse transcriptase inhibitor , telomere , stavudine , biology , immunology , in vitro , virus , sida , viral disease , polymerase chain reaction , hepatitis b virus , dna , biochemistry , genetics , gene

Human immunodeficiency virus (HIV)-infected patients on combination active antiretroviral therapy (cART) are at increased risk of age-related complications. We hypothesized that nucleos(t)ide reverse transcriptase inhibitors (NRTI) may contribute to accelerated aging in HIV-infected individuals on cART via inhibition of telomerase activity.

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