Combined Effects of Antenatal Receipt of Influenza Vaccine by Mothers and Pneumococcal Conjugate Vaccine Receipt by Infants: Results from a Randomized, Blinded, Controlled Trial | Zendy

Saad B. Omer | Zendy; Khalequ Zaman | Zendy; Eliza Roy | Zendy; Shams El Arifeen | Zendy; Rubhana Raqib | Zendy; Laila Noory | Zendy; Katherine Seib | Zendy; Robert F. Breiman | Zendy; Mark C. Steinhoff | Zendy

Open Access

Combined Effects of Antenatal Receipt of Influenza Vaccine by Mothers and Pneumococcal Conjugate Vaccine Receipt by Infants: Results from a Randomized, Blinded, Controlled Trial

Author(s) -

Saad B. Omer,

Khalequ Zaman,

Eliza Roy,

Shams El Arifeen,

Rubhana Raqib,

Laila Noory,

Katherine Seib,

Robert F. Breiman,

Mark C. Steinhoff

Publication year - 2013

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1093/infdis/jit003

Subject(s) - medicine , pneumococcal conjugate vaccine , vaccination , influenza vaccine , randomized controlled trial , pediatrics , confidence interval , pneumococcal vaccine , trivalent influenza vaccine , vaccine efficacy , clinical trial , immunology , streptococcus pneumoniae , antibiotics , microbiology and biotechnology , biology

A 2 × 2 factorial trial was performed to determine the efficacy of antennal influenza vaccination of mothers plus pneumococcal conjugate vaccination of their infants against respiratory illness during early infancy. The efficacy of trivalent inactivated influenza vaccine (TIV; delivered to mothers) plus 7-valent pneumococcal vaccine (PCV7; delivered to infants) was higher than the efficacy of TIV alone or PCV7 alone. During the period of the study in which influenza was circulating, the efficacy of TIV plus PCV7 was 72.4% (95% confidence interval, 30.2%-89.1%) against febrile respiratory illness and 66.4% (95% CI, 14.3%-86.9%) against medically attended acute respiratory illness.

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