Role of the Interleukin 10 Family of Cytokines in Patients With Immune Reconstitution Inflammatory Syndrome Associated With HIV Infection and Tuberculosis | Zendy

Rebecca Tadokera | Zendy; Katalin A. Wilkinson | Zendy; Graeme Meintjes | Zendy; Keira Skolimowska | Zendy; Kerryn Matthews | Zendy; Ronnett Seldon | Zendy; Molebogeng X. Rangaka | Zendy; Gary Maartens | Zendy; Robert J. Wilkinson | Zendy

Open Access

Role of the Interleukin 10 Family of Cytokines in Patients With Immune Reconstitution Inflammatory Syndrome Associated With HIV Infection and Tuberculosis

Author(s) -

Rebecca Tadokera,

Katalin A. Wilkinson,

Graeme Meintjes,

Keira Skolimowska,

Kerryn Matthews,

Ronnett Seldon,

Molebogeng X. Rangaka,

Gary Maartens,

Robert J. Wilkinson

Publication year - 2013

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1093/infdis/jit002

Subject(s) - immunology , tuberculosis , immune system , human immunodeficiency virus (hiv) , immune reconstitution inflammatory syndrome , medicine , interleukin , inflammation , virology , cytokine , pathology , viral load , antiretroviral therapy

The interleukin 10 (IL-10) family comprises cytokines structurally related to IL-10 that share signaling receptors that have conserved signaling cascades. The immunopathogenesis of immune reconstitution inflammatory syndrome (IRIS) in patients with human immunodeficiency virus (HIV) infection and tuberculosis remains incompletely understood. We hypothesized that a deficiency of IL-10 and its homologs may contribute to the immunopathology of IRIS in these patients.

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