Open AccessIL28B Single-Nucleotide Polymorphism rs12979860 Is Associated With Spontaneous HIV Control in White Subjects
Author(s) -
Kawthar Machmach,
Cristina Abad-Molina,
María Concepción Romero-Sánchez,
M. A. Abad,
Sara FerrandoMartínez,
Miguel Genebat,
Ildefonso Pulido,
Pompeyo Viciana,
María Francisca GonzálezEscribano,
Manuel Leal,
Ezequiel RuizMateos
Publication year - 2012
Publication title -
the journal of infectious diseases (online. university of chicago press)/the journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.69
H-Index - 252
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1093/infdis/jis717
Subject(s) - single nucleotide polymorphism , snp , genotype , biology , virology , odds ratio , human immunodeficiency virus (hiv) , hepatitis c virus , polymorphism (computer science) , interleukin 28b , hepatitis b virus , virus , immunology , genetics , gene , medicine
The single-nucleotide polymorphism (SNP) rs12979860 near the IL28B gene has been associated with the spontaneous clearance of hepatitis C virus. We sought to determine whether this SNP could be associated with the spontaneous control of human immunodeficiency virus (HIV) infection. We studied the prevalence of the IL28B CC genotype among 53 white HIV controllers, compared with the prevalence among 389 HIV-infected noncontrollers. We found that the IL28B CC genotype was independently associated with spontaneous HIV control (odds ratio [OR], 2.669; P = .017), as were female sex (OR, 7.077; P ≤ .001) and the presence of HLA-B57 and/or B27 (OR, 3.080; P = .017). This result supports the idea that common host mechanisms are involved in the spontaneous control of these 2 chronic infections.