Open AccessAssociation of Polymorphisms of the Mu Opioid Receptor Gene with the Severity of HIV Infection and Response to HIV Treatment
Author(s) -
Dmitri Proudnikov,
Matthew Randesi,
Orna Levran,
Howard Crystal,
Magdalena Dorn,
Jürg Ott,
Ann Ho,
Mary Jeanne Kreek
Publication year - 2012
Publication title -
the journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.69
H-Index - 252
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1093/infdis/jis264
Subject(s) - chemokine , chemokine receptor , human immunodeficiency virus (hiv) , receptor , μ opioid receptor , immunology , biology , chemokine receptor ccr5 , virology , opioid , virus , pathophysiology , medicine , inflammation , genetics , endocrinology
Mu opioid receptor (OPRM1) ligands may alter expression of chemokines and chemokine receptors involved in penetration of human immunodeficiency virus (HIV) type 1 into the cell. We suggest that OPRM1 variants may affect the pathophysiology of HIV infection.
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