A Computationally Optimized Hemagglutinin Virus-Like Particle Vaccine Elicits Broadly Reactive Antibodies that Protect Nonhuman Primates from H5N1 Infection | Zendy

Brendan M. Giles | Zendy; Corey J. Crevar | Zendy; Donald M. Carter | Zendy; Stephanie J. Bissel | Zendy; Stacey SchultzCherry | Zendy; Clayton A. Wiley | Zendy; Ted M. Ross | Zendy

Open Access

A Computationally Optimized Hemagglutinin Virus-Like Particle Vaccine Elicits Broadly Reactive Antibodies that Protect Nonhuman Primates from H5N1 Infection

Author(s) -

Brendan M. Giles,

Corey J. Crevar,

Donald M. Carter,

Stephanie J. Bissel,

Stacey SchultzCherry,

Clayton A. Wiley,

Ted M. Ross

Publication year - 2012

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1093/infdis/jis232

Subject(s) - influenza a virus subtype h5n1 , biology , virology , hemagglutinin (influenza) , clade , hemagglutination assay , virus , microbiology and biotechnology , titer , gene , phylogenetics , genetics

Highly pathogenic H5N1 avian influenza viruses continue to spread via waterfowl, causing lethal infections in humans. Vaccines can prevent the morbidity and mortality associated with pandemic influenza isolates. Predicting the specific isolate that may emerge from the 10 different H5N1 clades is a tremendous challenge for vaccine design.

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