Open AccessVaccination With Parenteral Toxoid B Protects Hamsters Against Lethal Challenge With Toxin A–Negative, Toxin B–Positive Clostridium difficile but Does Not Prevent Colonization
Author(s) -
Farida Siddiqui,
Jennifer R. O’Connor,
Kristin Nagaro,
Adam Cheknis,
Susan P. Sambol,
Gayatri Vedantam,
Dale N. Gerding,
Stuart Johnson
Publication year - 2011
Publication title -
the journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.69
H-Index - 252
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1093/infdis/jir688
Subject(s) - clostridium difficile , toxin , clostridium difficile toxin a , microbiology and biotechnology , clostridium difficile toxin b , toxoid , colonization , vaccination , medicine , virology , biology , immunology , antibiotics , tetanus
Toxin A has historically been regarded as the primary virulence determinant in Clostridium difficile infection, but naturally occurring toxin A-negative, toxin B-positive (A-/B+) C. difficile strains are known to be virulent. To determine the role of toxin B in these strains, we immunized hamsters with a toxoid prepared from purified toxin B to determine whether they would be protected from lethal challenge with an A-/B+ strain of C. difficile.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom