Open AccessGenetic Modification of the O-Polysaccharide of Francisella tularensis Results in an Avirulent Live Attenuated Vaccine
Author(s) -
Tae-Hyun Kim,
Jessica T. Pinkham,
Sara Heninger,
Sabina Chalabaev,
Dennis L. Kasper
Publication year - 2011
Publication title -
the journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.69
H-Index - 252
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1093/infdis/jir620
Subject(s) - francisella tularensis , virulence , biology , microbiology and biotechnology , attenuated vaccine , tularemia , virology , immunization , vaccination , antibody , gene , immunology , genetics
Francisella tularensis, the causative agent of tularemia, is a highly virulent microbe. One significant virulence factor of F. tularensis is the O-polysaccharide (O-PS) portion of the organism's lipopolysaccharide.
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